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KMID : 1149220040120010131
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Korean Journal of Oriental Medical Prescription
2004 Volume.12 No. 1 p.131 ~ p.148
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The Anti-tumor Effect of Bojungikkeehapdaechilkitang with Doxorubicin in 3LL
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Lee Yun-Hee
Byun Joon-Seok
Kim Bong-Suk
Oh Jung-Han
Lim Hee-Yong
Kim Dong-Woo
Choi Bin-Hye
Kim Sang-Chan
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Abstract
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In order to evaluate the anti-tumor and synergic effect of Bojungikkeehapdaechilkitang with doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and Bojungikkeehapdaechilkitang with their concomitant treatment against 3LL(Lewis lung carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to 3LL cell lines. Bojungikkeehapdaechilkitang has only mimic direct anti-tumor effect against to 3LL cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Bojungikkeehapdaechilkitang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and Bojungikkeehapdaechilkitang extracts.
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KEYWORD
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Bojungikkeehapdaechilkitang, doxorubicin, anti-tumor effect, 3LL
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